
Supporting pregnancy loss prevention
- 20-25% of pregnancies end in a miscarriage1
- 50-75% of women who suffer repeat miscarriages have an unknown cause2
New official UK medical guidance* recommends vaginal progesterone to reduce miscarriages
“Offer vaginal micronised progesterone 400mg twice daily to women with an intrauterine pregnancy confirmed by a scan, if they have vaginal bleeding and have previously had a miscarriage”

*NICE (UK) guideline (NG126), 24 Nov 2021 update
“Micronised vaginal progesterone treatment can therefore be considered for asymptomatic women with recurrent miscarriage, and is likely to be more effective in women with a high number of previous miscarriages”

Vol. 397 Number 10286 May 2021

Supporting IVF treatment
Daily progesterone doses are essential for IVF pregnancies, but current routes of administration have limitations

“Having gone through numerous IVF cycles – involving no end of injections and leaky suppositories – I know firsthand about the vital need for a better and patient-friendlier way of progesterone administration.”
Calla Lily Clinical Care Co-founder
Intramuscular/
subcutaneous injections are painful and expensive
“65.9% of patients found injections painful”
BMC NOV 2014 11:78
“I would have given anything to have an alternative to the 400 injections I had to self-administer over a period of just a few months”
K, IVF Patient
Callavid® is the injection-free alternative
Vaginal pessaries are uncomfortable and inconvenient, as once melted they leak out
Messy & irritating leakage
100% brought up leakage as an issue
Uncertain positioning & dosage
100% of users reported difficulties
~30 minutes of lying down
100% felt lying down was disruptive
Study conducted through medical market research firm Accellerate of 16 women undergoing IVF treatment using vaginal progesterone (not injections) during summer 2021
Oral delivery has significant side-effects including headaches, drowsiness and dizziness
Our device is the more comfortable & convenient, leakage-preventing solution
“Although vaginal suppositories are easier to tolerate, the suppository material may escape from the vagina, leading to inconvenience and uncertainty as to the dosage of progesterone absorbed”
NYU School of Medicine